What Quanto can read today: instruments, acquisition modes, raw data, and vendor methods. Formats land through add-ins under AddIns\ (see Installation and folders and Creating add-ins).

Platform

Item Requirement
OS Windows 10 or 11, 64-bit only
Runtime .NET 10 Desktop Runtime (x64), unless your installer bundles it
Host WPF desktop (Quanto.WPF.exe); not a service, not Linux

Sizing and Analyze performance: Hardware and performance.

Instruments and acquisition modes

Quanto is built for GC/LC–MS quantitative work on single quadrupole and triple quadrupole (QQQ) data.

Mode Meaning in Quanto Typical instrument
SCAN Full-scan MS1 extracted-ion chromatogram (EIC) Single quad GC-MS / MS1 scan
SIM Selected-ion monitoring Single quad
MRM / MS-MS Multiple-reaction monitoring (precursor → product) Triple quad (QQQ)
Combinations Mixed modes in one sample (e.g. SCAN+SIM) Supported where the vendor file exposes them

Internally, chromatogram extraction uses ChromatogramAcquisitionMode: Auto, Scan, Sim, MsMs. Auto detects from the file and tries alternates if a channel comes back empty. TIC for a mode is that mode’s primary TIC — not a sum of mixed modes.

MassHunter .D: detector classifies SingleQuadrupole vs QQQ / MRM / SIM / SCAN from the embedded acquisition method and scan types.

ChemStation .D: modes are SCAN, SIM, or ScanAndSim (data.ms / dataSim.ms). SIM windows can come from classic acqmeth.txt.

SCIEX WIFF: MRM transitions from the WIFF (Clearcore2 / SCIEX APIs).

Raw data (data providers)

Vendor Add-in (class) What you point at Notes
Agilent MassHunter AgilentMassHunterDataProvider .D sample folders Reads MassHunter data; may use Agilent TDA indexed-data conversion (TDAConverterConsole.exe) when indexed data is required for chromatogram access
Agilent ChemStation / MSD AgilentChemStationDataProvider .D sample folders Reads ChemStation data natively via Agilent MSDChem (MSDChemDataFile) — no TDA / format conversion step
SCIEX SciexWiff .wiff files Reads SCIEX WIFF through Clearcore2 / SCIEX vendor DLLs

All three also implement sample discovery (FindSamples) and fill common bottle metadata when present (name, acquired time, instrument, position, dilution, dose/level hints).

Vendor native DLLs ship under:

Method import (method importers)

Source Add-in (class) What you point at What comes in
MassHunter quant method AgilentMhMethod .m method folder (…\DaMethod\Quant\quantitative.xml) or .quantmethod.xml Compounds, ISTD flags, transitions, expected RT, curve hints
MassHunter method from data AgilentMassHunterDataMethod .D data folder Method inferred from acquisition / MRM content in the data file
ChemStation quant method AgilentCsMethod .M method folder containing qdb.mth Compounds from ChemStation QDB
SCIEX method from data SciexWiffMethod .wiff file MRM compounds / transitions built from the WIFF (standalone .msm is not supported with the current minimal SCIEX DLL set)
Quanto package (built-in host path) .qtm Full Quanto method (analytes, quants, doses, ISTD links, types, optional stored calibration and reports)

Import UX: Method → Load / Import — Replace or Append (Append uses a new AcqKey for multi-instrument / Key Review). Details: Reports, import, and export.

Vendor methods do not set Quanto’s Calibration mode; new work defaults to Initial calibration unless you change it.

Peak integration (integrators)

Integrator Role
Quanto Shipped high-performance peak detector (default on channels)
Slice Placeholder / alternate integrator slot (extensibility sample)

Per-channel integrator name and settings live on the method; custom integrators are add-ins (see Creating add-ins).

Capability checklist

Capability Status
Single Quad data (SCAN / SIM) Supported (MassHunter + ChemStation)
Triple Quad / QQQ data (MRM) Supported (MassHunter + SCIEX; ChemStation as exposed by MSDChem)
SCAN + SIM combinations Supported where the file layout exposes both (e.g. ChemStation ScanAndSim)
Import MassHunter method Yes (.m / .quantmethod.xml)
Import MassHunter method from data file Yes (from .D)
Import ChemStation method Yes (.M + qdb.mth)
Import SCIEX method from data file Yes (from .wiff)
Read MassHunter data Yes
Read ChemStation data without conversion Yes (native MSDChem)
Read SCIEX data Yes (.wiff)

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