After a full initial calibration you can Save Method. The .qtm keeps the curve responses (the Y values at C1…C5), not only the recipe. Later batches can re-run some levels. Quanto keeps the others.

Multi-batch partial update of dose responses A saved method keeps C1C5 responses. Later batches replace only the levels they re-ran. Partial update  each batch writes only the levels it ran Initial calibration can reuse responses stored in the method. A new batch replaces matching dose files and leaves the rest. Method after first full curve C1 kept C2 kept C3 kept C4 kept C5 kept Save Method (.qtm) stores these responses with the method. Batch A  only C3 was re-injected keep keep C3 update keep keep Analyze refits the curve: new C3 + method C1, C2, C4, C5. Batch B  C1 and C5 re-run, then Save Method C1 update keep C3 from A keep C5 update The method now mixes origins: C1 and C5 from B, C3 from A, C2 and C4 from the first curve. When this applies Calibration mode = Initial calibration (not bracketing). The batch has no full cal set, or only some levels. Quanto reuses method origins and response paths, then overwrites levels present in this batch. Bracketing never reuses saved origins. It fits only live calibration bottles in the run.
Method levels stay; Batch A updates C3; Batch B updates C1 and C5

When to use it

This is Initial calibration only. Bracketing always refits from live cal bottles in that batch and never reads saved origins.

How a batch updates the method

  1. First batch: full C1…C5, Analyze, review the curve, Method → Save Method.
  2. Next batch: add unknowns plus only the levels you want to refresh (for example C3).
  3. Analyze. Missing levels are filled from the method’s stored responses and calibration-sample origins.
  4. The new C3 response replaces the stored C3. C1, C2, C4, C5 stay.
  5. Save Method again if this batch should become the new source for the next one.

Origins remember file path and acquisition time. A response is replaced when this batch contains that calibration path (or the same dose in the live set). Other doses are left alone.

What is stored

The method package records, per Quant:

It does not store unknown samples. Those stay in the .qtb batch.

Practical rules

Reports and Key Review in each batch see the curve that batch actually fitted (mix of live + inherited points).